What is XEOMIN®?
XEOMIN® (zee-oh-min) is a neurotoxin therapy, available only by prescription, used to treat adults with cervical dystonia or adults with blepharospasm who have been previously treated with Botox® (onabotulinumtoxinA). The FDA approved XEOMIN® in 2010 for use in the United States for these conditions. The active ingredient in XEOMIN® is a type of botulinum toxin type A called incobotulinumtoxinA.
Where is XEOMIN® approved?
XEOMIN® has been FDA approved for use in the United States in adults with cervical dystonia or blepharospasm since 2010. It has also been approved since 2005 in Europe and is currently available in 43 countries worldwide. Over one million patients around the world have been treated with XEOMIN®.
Who is XEOMIN® for?
XEOMIN® is a prescription medicine used to treat: Adults with cervical dystonia (SUR-vi-kuhl dis-TOH-nee-uh) to help improve abnormal head position and neck pain Adults with blepharospasm (BLEF-er-oh-spaz-uhm) who have already been treated with Botox® (onabotulinumtoxinA) to help improve abnormal spasm of the eyelids
How is XEOMIN® made?
Merz, the maker of XEOMIN®, uses a proprietary manufacturing process to remove accessory proteins from botulinum toxin type A. These proteins do not play an active role in treatment. Learn more about the XEOMIN® purification process.
What is botulinum toxin type A?
Botulinum toxin type A is a neurotoxin used to treat symptoms of cervical dystonia and blepharospasm. When injected into muscles, this neurotoxin helps relax them by blocking signals from the nerves that can cause the muscles to spasm.
How is XEOMIN® given?
XEOMIN® is injected directly into the affected muscles. Your doctor will decide how many muscles need to be injected and the dose per muscle. For most people, the first effects of XEOMIN® are typically seen within 7 days. Everyone is different, so you should talk to your doctor if you have any questions or concerns about your treatment process.
How often will I need treatment with XEOMIN®?
The effects of XEOMIN® usually last about 12 weeks. These effects can last longer or shorter, depending on the person. Read more about what to expect from treatment with XEOMIN®.
What are the most common side effects of XEOMIN®?
In a clinical study of XEOMIN® for blepharospasm, the most common side effects included:
- Drooping eyelid
- Dry eye
- Dry mouth
- Visual impairment
- Difficult or labored breathing
- Inflammation of mucus membranes
- Respiratory infections
In a clinical study of XEOMIN® for cervical dystonia, the most common side effects included:
- Difficulty swallowing
- Injection site pain
- Neck pain
- Muscle weakness
- Muscle/joint pain
XEOMIN® may cause serious side effects that can be life threatening. Call your doctor or get medical help right away if you have any of these problems any time (hours to weeks) after treatment with XEOMIN®:
- Problems with swallowing, speaking, or breathing can happen after an injection of XEOMIN® if the muscles that you use to breathe and swallow become weak. If these problems are severe, you could die. People with certain breathing problems may need to use muscles in their neck to help them breathe and may be at greater risk for serious breathing problems with XEOMIN®.
- Swallowing problems may last for several months, and during that time you may need a feeding tube to receive food and water. If swallowing problems are severe, food or liquids may go into your lungs. People who already have swallowing or breathing problems before receiving XEOMIN® have the highest risk of getting these problems.
- Spread of toxin effects. In some cases, the effect of botulinum toxin may affect areas of the body away from the injection site and cause symptoms of a serious condition called botulism. The symptoms of botulism include: loss of strength and muscle weakness all over the body, double vision, blurred vision and drooping eyelids, hoarseness or change or loss of voice, trouble saying words clearly, loss of bladder control, trouble breathing, trouble swallowing.